Antihypertensive drugs and suicidal risk

This was a study done by a PharmD Mamdani in Canada

The patients were followed from 1995 to 2015. 


The most commonly used ACEIs were ramipril (38.8%) and enalapril (15.0%). The most commonly used ARBs were valsartan (16.7%), telmisartan (16.7%), and candesartan (16.7%).


Patients using ARBs had a 63% increased risk of death by suicide over people on ACE inhibitors, the findings showed. But the study could not prove a cause-and-effect relationship.

"There is reason for some concern," said lead researcher Muhammad Mamdani, director of the Applied Health Research Center of the Li Ka Shing Knowledge Institute at St. Michael's Hospital, in Toronto. "Now would I be going en masse and change everybody's prescriptions? No, not just yet. We should have more work done in this area."


Source :

Bhavin Dave, MD

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